Orlando will clinch a berth in the Audi 2021 MLS Cup Playoffs IF:
- Orlando win or tie vs. Montréal
or:
- New York lose vs. Nashville
or:
- Atlanta lose vs. Cincinnati AND
- Orlando win goal differential vs. Atlanta
Orlando will clinch a top-four seed in Eastern Conference IF:
- Orlando win vs. Montréal AND
- New York City lose vs. Philadelphia AND
- Atlanta lose or tie vs. Cincinnati
or:
- Orlando win vs. Montréal AND
- New York City lose vs. Philadelphia AND
- Orlando win goal differential vs. Atlanta